***AstraZeneca gets OK to sell asthma pills Accolate

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AstraZeneca gets OK to sell asthma pills Accolate, to kids Drug approval first since merger By CHERYL MEYER Staff reporter AstraZeneca Plc received federal approval to sell a new formula of its asthma-fighting pills to children as young as 7 years old, company executives said Monday. Previously, adults and children ages 12 and older could take Accolate, AstraZeneca’s oral drug for the respiratory disease. Accolate was officially launched for sale in November 1996. For years, many children under age 12 have relied on inhalers ….. Financial Times (London, England) – September 21, 1999 COMPANIES & FINANCE: UK: AstraZeneca may advertise drug NEWS DIGEST Pharmaceuticals, Pharmaceuticals AstraZeneca may advertise drug AstraZeneca is considering launching a new US advertising campaign to kickstart sales of Accolate, its asthma tablet, after winning approval from the US Food and Drug Administration for treatment of children as young as seven. Sales of Accolate, until now used only for mild to moderate asthma in adults and children above 12, have been flat this year. This has largely been because of competition in the US from ….. (New Jersey) – November 5, 1996 NEW DRUG FOR ASTHMA HELPFUL IN MANY CASES An entirely new class of drugs that could help as much as one-third of asthma sufferers and open up a new avenue for better medications is on the market. Doctors say Accolate, taken in pill form, can improve breathing for those with mild to moderate asthma, especially those who find carrying inhalers cumbersome and inconvenient. Known generically as zafirlukast, it is the first new class of asthma agents approved by the FDA in 20 years. Doctors began writing prescriptions for the ….. Guardian, The (London, England) – July 21, 1998 THE GUARDIAN: ASTHMA PILL ‘COULD REPLACE INHALERS’ FOR SOME SUFFERERS A NEW tablet that could replace inhalers for some of Britain’s 3 million asthma sufferers was launched yesterday. The drugs company Zeneca Pharmaceuticals says its anti-asthma pill Accolate is the first new treatment of its kind in Britain and the first alternative to inhaled steroids for 20 years. The tablet, taken twice a day to prevent an asthma attack, has been welcomed by the National Asthma Campaign, but the charity said it was too early to say which patients would ….. Scotsman, The (Edinburgh, Scotland) – July 21, 1998 The Scotsman: New drug hope for asthma sufferers A TABLET which could mean the end of inhalers for some asthma sufferers was made available in Britain yesterday. Doctors hope the pill, marketed by the drug company Zeneca as Accolate, will revolutionise asthma treatment. Zeneca claims it is the first alternative to inhaled steroids to be launched in Britain for 20 years. Although not all patients will be able to do without inhalers, the manufacturer believes it will provide a popular alternative for people on low-dose steroid ….. Chemical Business NewsBase: Press Release (United Kingdom) – June 15, 2009 Chemical Business NewsBase – Press Release: Four asthma drugs get new precaution. The FDA has asked makers of Singulair, Accolate, Zyflo, and Zyflo CR to include a precaution on those drugs’ labels about reports of behaviour and mood changes. Singulair is used to treat asthma and symptoms of allergic rhinitis. Accolate, Zyflo, and Zyflo CR are used to treat asthma. All four drugs are leukotriene inhibitors, which affect the leukotriene pathway, which is involved in the body’s response to inflammatory stimuli (such as breathing in an allergen). The FDA ….. THE ORLANDO SENTINEL – May 9, 2000 CHRONICALLY ILL SHOULD BE WARY OF CHITLINS In many parts of the southern United States, chitterlings – cleaned and boiled pig intestines, also known as chitlins – are a tradition. But a report suggests that this treat has the potential to be hazardous for people with diabetes and for others who are chronically ill. The report, in last week’s New England Journal of Medicine, said that the pig bowels can contain a bacterium called Clostridium perfringens type C, which produces a toxin that can cause a severe infection ….. Daily Telegraph (Sydney, Australia) – January 25, 1999 New help for asthma sufferers TWO pills to help prevent asthma attacks were among 36 new drug treatments approved in Australia last year. Singulair and Accolate, made by different drug companies, have undergone trials worldwide. The companies, Merck, Sharp and Dohme, and Zeneca, said yesterday the pills were selling for $90 to $110 for a month’s supply of Singulair or $90 to $130 for Accolate. A Zeneca spokeswoman said they would apply for Pharmaceutical Benefits Scheme listing in the hope Accolate …..

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