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Researchers working on two European Union-funded research projects have unravelled the structure of a key enzyme that can trigger allergies and asthma, giving hopes for more effective therapies, said the European Commission.
The enzyme, termed LTC4 synthase, is part of a complex process that leads to the production of leukotrienes, which cause allergic symptoms, and motors the inflammatory reaction, which causes asthma attacks.
Some of the existing medicines block the effect of this enzyme after the process has taken place. Thanks to these latest findings, scientists will now be able to tailor new molecules that block LTC4 before it can act.
The breakthrough was published in the leading scientific magazine Nature on Sunday.
The two projects, named EICOSANOX and E-MeP, are headed by professors from Karolinska Institutet in Stockholm and received 20 million euros ($27 million) of funding from EU’s research programme.
The EU-funded teams have developed the highest ever resolution picture of the structure of LTC4 synthase. This greater clarity of the structure of the enzyme means that scientists now have a much better understanding of how it is formed and how it works. This knowledge can then be used to develop more effective therapies.
Scientists from around the world have been working on unravelling the structure of LTC4 synthase and the results of two such projects are described in Nature this week.
The European team, however, has managed to produce the highest resolution information, therefore providing a much better template for drug design.
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When Devone regained consciousness an hour later, her life was changed. At 50, the Hempstead, N.Y., resident had joined the growing ranks of Americans afflicted with the baffling… , of 605 words 91. Chicago Sun-Times – March 20, 1999 Hispanics get asthma warning One of the first-ever studies of Hispanics and asthma was done in Chicago recently, and it came up with troubling news. The number of Hispanics with asthma is increasing, particularly among Puerto Rican children under age 1. What’s more, the number of asthma deaths among Hispanics also is on the rise. Very often, the study found, Hispanics died before ever getting medical care. Or, by the time Hispanics arrived at the emergency room, they were in such bad shape they could not be… , of 688 words 91. The Orange County Register – March 11, 1999 Asthma program debuts in O.C. HEALTH: Teachers, parents and children are to be taught how to prevent and treat the condition. The Orange County chapter of the American Lung Association kicked off the country’s first comprehensive asthma education program targeting day-care centers Wednesday, hoping to educate and train parents, teachers and children about the disease that affects one in 20 county children. The program, launched at the Buena Park Head Start, will become a model for lung association affiliates throughout the country, officials said. It is being rolled out in Head Start centers throughout… , of 905 words 91. *- February 4, 1999 $68M IS A START VS. ASTHMA IN QUEENS, where ,000 school children suffer from asthma, Hillary Rodham Clinton’s announcement last Thursday that the President’s budget would include $68 million to combat asthma nationwide is welcome news. Queens children suffer from asthma in disproportionate numbers. The problem is compounded in the areas near the airports. It is a very serious problem in southeast Queens, says Tara Fleming, director of public affairs at the Jamaica… , of 689 words 91. Daily Press Newport News, VA – October 8, 1998 ASTHMA DRUG COULD AVERT HOSPITAL STAY Adding a drug to common treatments for severe asthma attacks could help many children avoid a hospital stay, according to a new study done at Children’s Hospital of the King’s Daughters.Emergency room doctors found that use of ipratropium bromide, a plant-based medicine, led to a 15 percent reduction in hospitalizations for children with severe attacks. The study, a joint project of CHKD and Eastern Virginia Medical School, was published today in the New England… , of 7 words 91. St. Louis Post-Dispatch – April 24, 1998 EXPERT BLAMES POLLUTION FOR INCREASED ASTHMA CASES RISE BY 75 PERCENT SINCE 1980, CDC WARNS AND MORE INCIDENCES TURN DEADLY The number of Americans who suffer from asthma has risen 75 percent since 1980 to more than 15 million, in part due to pollution and other environmental factors, federal health officials said Thursday.The Centers for Disease Control and Prevention said the number of doctors’ office visits for asthma treatment had more than doubled since 1975. There were more than 1.8 million emergency room visits for asthma in 1995. The agency said the increase in asthma cases spanned all… , of 4 words 91. *- February 25, 1998 LIVING AND BREATHING IT There are an estimated 500,000 ers with asthma who fight a daily battle to breathe. This is the story of five people who have learned to cope with the disease. Denise Dennis, 44, of Harlem, has waged her fight against asthma on two fronts.The disease itself sent her to St. Luke’s Hospital, choking and wheezing, more than 20 times over an eight-year period. Each episode was terrifying for Dennis, a single woman who lived alone. But the cure was almost as bad.Doctors… , of 1217 words 91. *- June 2, 1997 ASTHMA UNDER ATTACK, Harbor-UCLA researcher looks for genetic causes He was just out of medical school when he decided how he would attack the mystery of asthma.He would go down to the molecule to look for the cause of the complicated disease. Dr. Chad K. Oh now spends most of his time isolating genes in search of solid evidence of the genetic roots of asthma, findings that could lead to a treatment far superior to today’s asthma medications.
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