Asthma treatment

161. – February 23, 1998 Big Movers in the Stock Market Some of the stocks that moved substantially or traded heavily Monday on the New York Stock Exchange, Nasdaq Stock Market, and American Stock Exchange. NYSE Merck, up 5 15/16 at 130 5/8 The Food and Drug Administration cleared the drugmaker to begin selling its Singulair asthma drug next month. Singulair is one of a new class of oral asthma drugs that targets the causes of the disease, rather than symptoms. The first such drug to win FDA approval was Zeneca ….. Bismarck Tribune, The (ND) – April 1, 2008 Link between suicide, Singulair investigated WASHINGTON (AP) – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a ….. Winchester (VA) – March 28, 2008 FDA probes Singulair, suicide WASHINGTON – The Food and Drug Administration is investigating a possible link between Merck’s best-selling Singulair drug and suicide. FDA said on Thursday that it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it is part of a class of ….. (NJ) – March 28, 2008 FDA probes possible link of Singulair with suicide The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken Merck’s popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of ….. (CA) – February 10, 1997 NEW ASTHMA DRUGS CAN HELP PREVENT SYMPTOMS Regular use of one of the first of a new class of asthma drugs can help prevent symptoms in people with mild to moderate asthma, according to a new study. Of 146 asthmatics who used inhalers as needed, those who also took zafirlukast (sold as Accolate) daily for 13 weeks had 90 percent more days without asthma symptoms and 98 percent more days without episodes of asthma that disturbed their sleep or limited their activity than those who took placebo instead of zafirlukast. Zafirlukast ….. – June 15, 2009 FDA asks for warning on some asthma drugs The U. S. Food and Drug Administration has asked manufacturers to include a precaution in the labeling of some asthma drugs called leukotriene modifiers. The federal agency said the labeling should advise patients that some neuropsychiatric events have been reported by people taking montelukast (Singulair), zafirlukast (Accolate) and zileuton (Zyflo and Zyflo CR). Leukotrienes are chemicals the body releases in response to an inflammatory stimulus, such as when a person breathes in an ….. (MI) – March 28, 2008 In Brief FDA probing possible link between Singulair, suicide WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, ….. – June 23, 1997 ALLERGY POLICE // DOCTOR INVESTIGATES MEDICINES THAT COULD BRING SIGH OF RELIEF Dr. Anjuli Nayak likes to treat today’s patients with tomorrow’s medicine. Nayak is a local allergist. In her practice, she and her staff determine what patients are allergic to, then – if appropriate – give them injections of an allergen to gradually build up their immunity. That’s not unusual. There are several allergists in Bloomington-Normal. What is unusual is what goes on next door to her practice at 1300 Franklin Ave. , Suite 180, …. – March 28, 2008 FDA investigating link between allergy drug, suicide WASHINGTON — The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, ….. (WV) – March 28, 2008 FDA checking reported Singulair-suicide link WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the United States, according to Merck. First approved in 1998, it’s ….

151. Evening Standard, The (London, England) – January 27, 1998 EVENING STANDARD: BUSINESS DAY: DRUGS SET UP ZENECA FOR AN EARNINGS HIGH DRUGS group Zeneca said today a better-than-expected performance from its pharmaceuticals side, particularly new products, should enable it to report earnings above its “aspirational growth rate” of 15% this year. Following a downturn on the agrochemicals side, however, the group said its trading performance for 1997 is expected to be “in line with market expectations”. Sales growth on the pharmaceuticals side accelerated in the fourth ….. Aberdeen Press & Journal (Scotland) – September 30, 2004 Aberdeen Press & Journal (UK): Farmlay top egg producer A North-east egg producer has won its second business accolade in a month. Strichen-based Farmlay Eggs, which earlier this month won Scotland’s best small busi- ness crown, has now been named the country’s top egg producer. The new accolate came during the Scottish Egg Quality Awards, which were decided at the Scottish Agricultural College’s Auchincruive cam-pus. Farmlay, run by husband and wife Robert and Ethel Chapman, faced competition from 20 ….. – February 23, 1998 Big Movers in the Stock Market Some of the stocks that are moving substantially or trading heavily today on the New York Stock Exchange, Nasdaq Stock Market, and American Stock Exchange. NYSE Merck, up 4 at 128 11/16 The Food and Drug Administration cleared the drugmaker to begin selling its Singulair asthma drug next month. Singulair is one of a new class of oral asthma drugs that targets the causes of the disease, rather than symptoms. The first such drug to win FDA approval was Zeneca ….. Bridgeton News (NJ) – March 28, 2008 FDA probes possible link between allergy drug, suicide WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a ….. – March 28, 2008 FDA investigates possible Singulair, suicide link The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a class of asthma ….. – March 28, 2008 FDA probes suicide link to Singulair The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a class of asthma and ….. (FL) – May 5, 2007 How Should Pregnant Women Deal With Asthma? , By DENNIS LEDFORD, M. D. Tribune correspondent Asthma is one of the most common chronic conditions affecting pregnancy. Approximately 4 percent to 8 percent of pregnant women suffer from asthma. Women whose asthma is well controlled throughout pregnancy have an excellent chance for a normal pregnancy and a healthy baby. However, severe or poorly treated asthma is associated with premature birth, increased need for Caesarean sections, elevated blood pressure for the mother and growth retardation for the ….. wire Europe – February 23, 2006 SecurStar Wins International Security Award 2006 PRNewswire — Awarded in Best Disk Encryption, Best Email Security Solution, and Best Desktop Firewall Categories SecurStar GmbH with headquarter in Germany announced that the company’s products have gained SC Magazine Awards 2006. SecurStar’s encryption solutions have convinced readers as well as jury in all categories in which the company competed (best disk encryption, best email security solution, and best desktop firewall). With more than 1, 300 nominated products ….. MondayMorning (USA) – September 27, 1999 FDA ROUNDUP:. Careside Inc. (Culver City CA) was cleared to sell its test to detect carbon dioxide levels in blood. The test measures the total CO2 concentration in anti-coagulated blood, plasma, and serum, which aids in the diagnosis and treatment of patients with respiratory, kidney and metabolic disorders. * * Nidek Inc. (Fremont CA) received clearance to market its EAS-1000 Anterior Eye Segment Analysis System. The EAS-1000 is designed to provide clear, distinct anterior segment imaging of all pertinent ….. – February 23, 1998 Big Movers in the Stock Market Some of the stocks that are moving substantially or trading heavily today on the New York Stock Exchange, Nasdaq Stock Market, and American Stock Exchange. NYSE Merck, up 5 15/16 at 130 5/8 The Food and Drug Administration cleared the drugmaker to begin selling its Singulair asthma drug next month. Singulair is one of a new class of oral asthma drugs that targets the causes of the disease, rather than symptoms. The first such drug to win FDA approval was Zeneca ….

321. AFX-CNF (UK) – April 24, 2008 AFX CNF: AstraZeneca PLC – 1st Quarter Results (1 of 2) RNS Number:0196T AstraZeneca PLC 24 April 2008 AstraZeneca PLC First Quarter Results 2008 – Core EPS increased by 9 percent at CER to $1. 28. – First quarter sales increased by 4 percent at CER to $7, 677 million. – Inclusion of MedImmune sales more than offset the decline in Toprol-XL((TM)) sales in the US. – Strong growth in Emerging Markets, with sales up 11 percent at CER. – Underlying business performance on track. Core EPS target increased to reflect year to date currency impact. – Revised ….. (NC) – April 24, 2008 Asthma poses serious health problem for children H HENDERSONVILLE— Asthma is the leading serious chronic illness of children in the U. S. , and it is the third leading cause of hospitalization among children younger than 15, according to the American Lung Association. This week, Dr. Chona S. Reguyal with Western Carolina Medical Associates in Fletcher answers some frequently asked questions about asthma. Question: What are the warning signs of asthma in children? Answer: Difficulty breathing, fast or rapid breathing, …. – April 3, 2008 IN BRIEF Sports Study suggests high mound a factor in pitchers’ injuries As baseball season begins, pitchers will stand atop regulation-height, 10-inch mounds to wind up. Then they’ll stride, cock their arms, accelerate, decelerate and follow through to release a ball that can reach speeds of 100 mph. Now, a motion analysis study of 20 elite pitchers from the major leagues and NCAA Division I-A college teams suggests that a 10-inch mound, also standard for high school ….. (FL) – March 29, 2008 ALLERGY DRUG RISK FAR FROM CERTAIN Patients with asthma and allergies called doctors across Tampa Bay Friday, worried as Singulair became the latest blockbuster drug hit by safety questions. But right now, the biggest safety threat is that asthma patients might stop the drug without talking to their physicians first, some bay area doctors said Friday. “What I would not want to see is somebody having a flare-up with their asthma and ending up in the E. R. because of (worry about) an event that’s ….. Montgomery Advertiser (AL) – March 29, 2008 FDA looks into Singulair The Food and Drug Administration is investigating anecdotal reports that people who use Singulair, the popular asthma and allergy drug, are at greater risk for suicidal thoughts and suicide. Singulair is a pill prescribed to treat asthma and hay fever symptoms. It blocks an inflammation pathway in the body that can cause both asthma and allergy symptoms. It was approved for treating asthma in 1998, and to treat seasonal allergy symptoms in 2003. In the past year, drugmaker Merck, of ….. – March 28, 2008 FDA investigates possible link between drug, suicide MATTHEW PERRONE AP Business Writer WASHINGTON (AP) – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing reports of mood changes, suicidal behavior and suicide in patients who have taken the popular allergy drug. Merck has updated the drug’s labeling four times in the past year to include information on a range of side effects: tremors, anxiousness, ….. (CA) – March 28, 2008 Possible drug, suicide link probed, FDA looks into reports involving best-selling Singulair by Merck WASHINGTON – The Food and Drug Administration said Thursday that it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. Merck has updated the drug’s labeling four times in the past year to include information on a range of reported side effects: tremors, anxiousness, ….. – March 28, 2008 Green Zone Lockdown: Diplomats Ordered Inside Suicide Link to the Drug Singulair? Sen. Bill Nelson’s Plan to Elect a President Dad Saves Son Who Fell in the Well KIRAN CHETRY, ANCHOR: Meanwhile, though, we have breaking news and rising tensions in Baghdad this morning. New moves from the prime minister of Iraq, Nuri al-Maliki. Iraq’s parliament convenes a special session this morning to address days of fighting that has been taking place between government troops and Shiite militias. U. S. diplomats in Baghdad are being warned to stay under cover until further notice after repeated rocket attacks into the Green Zone. Two U. S ….. 329. USA TODAY (Arlington, VA) – March 28, 2008 FDA looks into Singulair, risks of suicidal thoughts, Anecdotal reports from doctors, patients studied The Food and Drug Administration is investigating anecdotal reports that people who use Singulair, the popular asthma and allergy drug, are at greater risk for suicidal thoughts and suicide. Singulair is a pill prescribed to treat asthma and hay fever symptoms such as sneezing and a nose that is stuffy, runny or itchy. It blocks an inflammation pathway in the body that can cause both asthma and allergy symptoms. It was approved for treating asthma in 1998 and to treat seasonal …. – March 28, 2008 ‘Marketplace’ Report: Singulair Suicide Link? MADELEINE BRAND, host: From N , this is Day to Day. Federal regulators are looking into possible safety problems with the widely used asthma drug Singulair. There have been anecdotal reports of a link between Singulair and suicidal behavior. The Food and Drug Administration says it is investigating three or four suicides. Marketplace’s Bob Moon is here now, and Bob, is the FDA saying consumers should immediately stop taking this drug until they’ve concluded ….

311. – 5 KFSM (Fort Smith-Fayetteville-Springdale-Rogers, AR) – June 15, 2009 KFSMMORN – 06:00:12 TIME START: 06:00:12 OMAHA ….WE’LL HAVE THE DETAILS ON TONIGHT’S GAME COMING UP ….THANKS FOR WAKING UP WITH FIVE NEWS THIS MORNING. IT’S MONDAY JUNE 14TH I’M ASHLEY BECK. HERE’S WHAT’S COMING UP IN THIS MORNING’S TOP STORIES ….. THIS WEEKEND’S SEVERE WEATHER LEFT MANY CLEANING UP ….WE’LL TAKE A LOOK AT THEIR PROGRESS, PLUS TALK ABOUT CHANGES COMING TO ….. – June 15, 2009 Health and Science News NASA schedules new launch dates CAPE CANAVERAL, Fla. , June 15 (UPI) — Space shuttle Endeavour’s next launch attempt has been set for 5:40 a. m. EDT Wednesday from the Kennedy Space Center in Florida. As a result of the shuttle re-scheduling, the National Aeronautics and Space Administration said its Lunar Reconnaissance Orbiter and Lunar Crater Observation and Sensing Satellite will lift off together Thursday aboard an Atlas V rocket Thursday. NASA officials say they have ….. Newstex Blogs (USA) – June 13, 2009 Twitter activity by Drug Injury Watch Jun. 12, 2009 ( Newstex Newstwits delivered by Newstex) RT @pharmalot: Lilly sold Zyprexa for dementia knowing it was useless for the ailment http://bit. ly/kDOec 06-12-2009 at 12:09:45 UTC Merck’s Lack of Social Responsibility Exposed [re phony medical journals] (Reputation Report, 6/10/09) http://bit. ly/OGmAT 06-12-2009 at 12:15:53 UTC RT @InVivoBlogChris: Ah, olde-timey drug ads are a blast. heroin, for coughs! tooth ache? try cocaine! ….. – June 12, 2009 FDA flags psychiatric risks of asthma drugs New labels on popular asthma drugs like Merck’s Singulair must highlight language about suicidal behavior, depression and anxiety seen in a small number of patients, federal regulators said Friday. After 15 months of investigation, the Food and Drug Administration said Merck & Co. Inc. , AstraZeneca and Cornerstone Therapeutics will have to raise label warnings about psychiatric problems reported by a handful of patients taking their drugs ….. . azcentral. com (AZ) – June 12, 2009 FDA flags psychiatric risks of asthma drugs ….. Liverpool Echo (England) – April 4, 2009 Liverpool Echo: City stars so Scouse proud FOOTBALL legends, artists, businessmen and media figures were among the first round of official “Honorary Scousers”. The Lord Mayor of Liverpool will bestow the coveted title upon nearly 40 people who have made the city their home and become some of its top ambassadors. Some obvious choices, such as Danish footballer Jan Molby and RLPO conductor Vasily Petrenko, sit alongside more unexpected names such as Wirral-raised DJ Pete Price. All will be attending an ….. Morning Sun, The (Mount Pleasant – Alma, MI) – January 14, 2009 Features IN BRIEF STDs up; might be the testing ATLANTA (AP) – Sexually spread diseases – for years on the decline – are on the rise in the United States, with reported chlamydia cases setting a record, government health officials said Tuesday. The increase in chlamydia, a sometimes symptomless infection that can lead to infertility in women, is likely because of better screening, experts said. In 2007, there were 1. 1 million cases, the most ever reported, said officials at the Centers for ….. (NJ) – January 14, 2009 World, Nation and State briefs b>Indonesia / Osama bin Laden courier goes on trial JAKARTA — A Singaporean who was a courier for Osama bin Laden before the Sept. 11, 2001 attacks went on trial in Indonesia on Tuesday with nine other suspected Islamic militants. The case highlights the lingering threat in Indonesia, home of the 2002 Bali nightclub attacks that thrust the world’s most populous Muslim nation onto the front lines in the war on terror. The indictment said the men are believed …. (Dubuque, IA) – July 28, 2008 Working out a Diagnosis The symptoms A child might have exercise-induced asthma if he or she: 3 Feels winded or tired easily during or after exercise. 3 Coughs when he or she comes inside from playing outdoors. 3 Cannot run for more than a few minutes without stopping. Children with exercise-induced asthma often begin experiencing symptoms five to 10 minutes after they start exercising. Symptoms usually peak five to 10 minutes after stopping the activity and might take an hour or longer to subside. Source: Nemours ….. (Hopkinton, RI) – May 29, 2008 RX home NEWS RX ASK THE PHARMACIST Allergy drugs: the side effects and the damage they might cause Q: I usually start taking Singulair ® for my allergies around this time of year. Should I opt for something else since the recent reports of increased suicide with this drug? A: Singulair ® , or montelukast is a widely used medication for the treatment of asthma or allergic rhinitis. Patients tend to prefer it because it is oral and not inhaled, like many ….

331. Chronicle Herald, The (Halifax, Nova Scotia, Canada) – March 28, 2008 Link between allergy drug, suicide probed WASHINGTON – The U. S. Food and Drug Administration is investigating a possible link between Merck’s bestselling Singulair and suicide. The FDA says it is reviewing reports of mood changes, suicidal behaviour and suicide in patients who have taken the popular allergy drug. Merck has updated the drug’s labelling four times in the past year to include information on a range of side-effects: tremors, anxiousness, depression and suicidal behaviour. The FDA says it ….. Sauk Valley Newspapers (Dixon-Sterling, IL) – March 28, 2008 FDA looks into Singulair, reports of suicidal thoughts Gannett News Service The Food and Drug Administration is investigating anecdotal reports that people who use Singulair, the popular asthma and allergy drug, are at greater risk for suicidal thoughts and suicide. Singulair is a pill prescribed to treat asthma and hay fever symptoms such as sneezing and a nose that is stuffy, runny or itchy. It blocks an inflammation pathway in the body that can cause both asthma and allergy symptoms. It was approved for treating asthma in 1998, and …. – March 28, 2008 Singulair-suicide reports probed The Food and Drug Administration said yesterday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. Merck has updated the drug’s labeling four times in the past year to include information on a range of reported side effects: tremors, anxiety, depression and ….. – March 28, 2008 Merck asthma pill probed by FDA for link to suicide The Food and Drug Administration, raising yet another red flag about drug safety, said yesterday it is investigating a possible association between Merck’s top-selling allergy and asthma drug Singulair and suicide. In an alert to patients and doctors, the FDA said it is working with the New Jersey drugmaker to evaluate whether the heavily prescribed medicine is linked to mood changes, suicidal thinking and behavior and to suicide. The FDA said patients should not ….. – March 28, 2008 World Briefly Lt. Gen. Martin Dempsey set to assume command of wars in Iraq and Afghanistan WASHINGTON (AP) — One of the Army’s most Iraq- generals is taking charge, at least temporarily, of arguably the most important command in the U. S. military, with responsibility for the wars in Iraq and Afghanistan. In a ceremony Friday at MacDill Air Force Base, Fla. , Lt. Gen. Martin Dempsey is to assume command of U. S. Central Command from Navy Adm. William J. Fallon, who announced ….. – March 28, 2008 ALLERGY DRUG UNDER REVIEW, POSSIBLE SUICIDE LINK CITED The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. Merck has updated the drug’s labeling four times in the past year to include information on a range of reported side effects: tremors, anxiousness, depression and ….. Waterloo Region Record (Ontario, Canada) – March 28, 2008 Allergy drug probe launched U. S. and Canadian drug regulators are investigating the popular allergy medication Singulair in response to reports of mood changes, suicidal behaviour and suicide in patients. The U. S. Food and Drug Administration said yesterday it is reviewing a handful of such patient reports and has asked Singulair’s maker, Merck & Co. , to dig deeper into its data for more evidence of possible links to suicide. Meanwhile, “patients should not stop taking Singulair ….. Portsmouth Daily Times (OH) – March 28, 2008 FDA investigates possible Singulair suicide link WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Mercks’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. Merck has updated the drug’s labeling four times in the past year to include information on a range of reported side effects: tremors, anxiousness, ….. Times Argus, The (Montpelier-Barre, VT) – March 28, 2008 Merck’s Singulair drug under suicide probe WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. Merck has updated the drug’s labeling four times in the past year to include information on a range of reported side effects: tremors, anxiousness, ….. FD (FAIR DISCLOSURE) WIRE – March 27, 2008 Q4 2007 Critical Therapeutics, Inc. Earnings Conference Call – Final OPERATOR: Good afternoon, everyone, and welcome to Critical Therapeutics fourth quarter and year end 2007 financial results conference call. There will be an opportunity for questions and comments after the prepared remarks. (OPERATOR INSTRUCTIONS) At this time, I’d like to turn the call over to Ms. Linda Lennox, Vice President, Investor and Media Relations. Please go ahead, Ms. Lennox. LINDA LENNOX, VP, IR AND MEDIA RELATIONS, CRITICAL THERAPEUTICS, INC. : Thank you ….

351. (NY) – June 28, 2006 Alternative asthma treatments Breathe deeply. This simple act sustains life, yet most of the time we don’t even notice it. Not being able to catch your breath can be terrifying. People with asthma may gasp desperately for air. Sometimes they even die with their inhalers in their hands. Asthma deaths have been rising for decades, although the drugs to treat it are more powerful than ever before. Researchers now blame some of the most popular asthma drugs for this increased mortality. A new analysis ….. Lawton Constitution, The (OK) – June 28, 2006 Asthma meds may need to be reconsidered Breathe deeply. This simple act sustains life, and yet most of the time we don’t even notice it. Not being able to catch your breath can be terrifying. People with asthma may gasp desperately for air. Sometimes they even die with their inhalers in their hands. Asthma deaths have been rising for decades, although the drugs to treat it are more powerful than ever before. Researchers now blame some of the most popular asthma drugs for this increased mortality. A new analysis ….. FD (FAIR DISCLOSURE) WIRE – April 27, 2006 Q1 2006 CuraGen Corporation Earnings Conference Call – Final OPERATOR: Good morning. My name is Tamara and I will be your conference operator today. At this time, I would like to welcome everyone to the CuraGen First Quarter 2006 Results Conference Call. [OPERATOR INSTRUCTIONS] I will now turn the call over to Dr. Glenn Schulman, head of Investor Relations. Dr. Schulman, you may begin your conference. GLENN SCHULMAN, INVESTOR RELATIONS, CURAGEN CORPORATION: Thank you everyone. Good morning and welcome to CuraGen Corporation’s first …. (CA) – April 4, 2006 Alternative asthma medications are available Dear Dr. Donohue: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her? – M. D. Dear M. D. : Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage of air ….. Times Union, The (Albany, NY) – April 4, 2006 Prednisone not the only drug used to treat asthma DEAR DR. DONOHUE: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Would another drug work? – M. D. DEAR M. D. : Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage of air into and out of the lungs ….. (FL) – April 4, 2006 PREDNISONE ONLY ONE OF MANY ASTHMA DRUGS DEAR DR. DONOHUE: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her? — M. D. ANSWER: Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage of ….. American Press (Lake Charles, LA) – April 4, 2006 Prednisone only one of many asthma drugs Dear Dr. Donohue : My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years , and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her ? — M. D. Answer : Asthma makes people ‘ s airways ( bronchi ) very sensitive to the slightest irritation. If they breathe things that wouldn ‘ t bother the rest of us , their airways constrict , and ….. South Florida Sun-Sentinel (Fort Lauderdale, FL) – April 4, 2006 TRY A NEW ASTHMA MEDICINE Dear Dr. Donohue: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her? — M. D. Dear M. D. : Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage …. (CA) – April 4, 2006 Alternative asthma medications are available Dear Dr. Donohue: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her? – M. D. Dear M. D. : Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage of air ….. (MI) – April 4, 2006 Asthma drug brings weighty side effects Dear Doctor: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her? — M. D. M. D. : Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage of air into ….

341. – March 27, 2008 FDA investigating possible link between Merck’s Singulair allergy drug and suicide The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. Merck has updated the drug’s labeling four times in the past year to include information on a range of reported side effects: tremors, anxiousness, depression and ….. FD (FAIR DISCLOSURE) WIRE – March 27, 2008 Q4 2007 Critical Therapeutics, Inc. Earnings Conference Call – Final OPERATOR: Good afternoon, everyone, and welcome to Critical Therapeutics fourth quarter and year end 2007 financial results conference call. There will be an opportunity for questions and comments after the prepared remarks. (OPERATOR INSTRUCTIONS) At this time, I’d like to turn the call over to Ms. Linda Lennox, Vice President, Investor and Media Relations. Please go ahead, Ms. Lennox. LINDA LENNOX, VP, IR AND MEDIA RELATIONS, CRITICAL THERAPEUTICS, INC. : Thank you …. – February 1, 2008 When the nose knows no relief By NEERAV GOYAL and ALOK GOYAL MD SPECIAL TO DESINJ Do you ever feel as if your cold is not going away? Has it been over a week? Do you have toothaches, headaches, or feel other pressures like pain around your face? Are you noticing a yellowish greenish discharge when you blow your nose? It may be that you no longer simply have a cold. You may also have sinusitis, an inflammation of your sinuses. There are four pairs of sinuses, three of which are located around the front of ….. (TX) – November 24, 2007 Walter C. Stephens Jr. Services for Walter C. Stephens Jr. , 81, of Lubbock will be at 2 p. m. Saturday, Nov. 24, 2007 at Vandelia Church of Christ with Mr. Doug Hale officiating. Interment will follow in Resthaven Memorial Park under the direction of Resthaven Funeral Home. Mr. Stephens passed away Nov. 21, 2007 in Lubbock He was born Oct. 5, 1926 in Quanah to the late Walter C. Sr. and Dessie Faye (Gist) Stephens. He grew up in and around Childress County. He married Roxie Ann Arnn Aug. 19, 1946. She preceded him ….. – 8 KLAS (Las Vegas, NV) – November 15, 2007 Morning News – 05:00:14 TIME START: 05:00:14 S ACCIDENTALLY SHOT OVERNIGHT ….AFTER OPENING HER DOOR DURING A SHOOTING. WE’LL HAVE DETAILS. > THE PODIUMS ARE SET ….THE CABLES ARE LAID ….AND TONIGHT ….THE EYES OF THE NATION WILL BE ON NEVADA. EVERY MAJOR DEMOCRATIC CANDIDATE FOR PRESIDENT IS HERE FOR A HIGH-PROFILE DEBATE. WE’RE LIVE WITH DETAILS PLUS: > AT LEAST ONE OF THE REPORTERS IN THE CROWD TONIGHT WILL BE THIS FIFTH ….. Observer, The (London, England) – June 10, 2007 The Observer: ALLERGIES: Asthma: Every six hours someone in Britain dies, gasping for breath, from this chronic condition Britain, the US, Australia and New Zealand share the unhappy similarity of having the world’s highest asthma rates, with one in every five households having a sufferer – and no one really knows why. The burden it places on children and adults is considerable and is largely not understood by people who have never experienced it. In Britain, a child is admitted to hospital with asthma every 19 minutes and one person dies of it every six hours. If this were a new infectious disease, ….. EDGAR Online 8-K Glimpse (USA) – March 30, 2007 8-K: MEDICINOVA INC ——————————————————————————– UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D. C. 20549 ——————————————————————————– FORM 8-K ——————————————————————————– CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): ….. – February 2, 2007 AstraZeneca to eliminate 3, 000 jobs by 2010 By GARY HABER The News Journal AstraZeneca PLC plans to eliminate 3, 000 manufacturing and distribution jobs during the next three years, the company said Thursday. The cuts, which represent about 4. 6 percent of AstraZeneca’s worldwide work force of about 65, 000, come as the United Kingdom’s second-largest pharmaceutical maker moves to shrink manufacturing capacity in the face of generic competition to its Toprol-XL high blood pressure drug, and after it …. 349. (TN) – December 20, 2006 Living with asthma: The role of education, communication, medication Asthma is one of the most common chronic diseases in the United States, affecting more than 20 million people, including nine million under the age of 18. Acute attacks result in two million emergency room visits and 500, 000 admissions to hospitals every year. In 2001 there were more than 5, 000 deaths from asthma. Untreated, the disease can progress to marked respiratory disability in some individuals. People who have asthma may experience a number of symptoms. The symptom that is most ….. , The (IL) – November 18, 2006 BRIEFS College soccer McKendree’s Holmeswins league honor LEBANON – McKendree College soccer player Jarius Holmes of O’Fallon has been named the American Midwest Conference’s Newcomer of the Year, awarded each season to the league’s top transfer player. Holmes, a junior forward, came to McKendree from Southwestern Illinois College in Belleville. He was second on the Bearcats in scoring with 15 points (five goals, five assists). Holmes ….

371. (FL) – August 12, 2005 CAUSE OF CHRONIC HIVES OFTEN NOT FOUND DEAR DR. DONOHUE: I have had hives for almost three years. They pop up anywhere on my body. Sometimes my hands swell, too. I have seen a dermatologist, an allergist and a rheumatologist. Nothing has worked so far. Do you have any ideas? — D. F. ANSWER: Allergies, medicines such as ACE inhibitors and anti-inflammatory drugs, thyroid-gland disorders, parasite infections and illnesses like lupus are some of the hidden causes of recurrent crops of hives. You have seen three specialists, all ….. (FL) – August 12, 2005 CAUSE OF CHRONIC HIVES OFTEN NOT FOUND DEAR DR. DONOHUE: I have had hives for almost three years. They pop up anywhere on my body. Sometimes my hands swell, too. I have seen a dermatologist, an allergist and a rheumatologist. Nothing has worked so far. Do you have any ideas? — D. F. ANSWER: Allergies, medicines such as ACE inhibitors and anti-inflammatory drugs, thyroid-gland disorders, parasite infections and illnesses like lupus are some of the hidden causes of recurrent crops of hives. You have seen three specialists, all ….. (NY) – August 12, 2005 CAUSE OF HIVES MIGHT NOT BE FOUND Dear Dr. Donohue: I have had hives for almost three years. They pop up anywhere on my body. Sometimes my hands swell, too. I have seen a dermatologist, an allergist and a rheumatologist. Nothing has worked so far. Do you have any ideas? – D. F. Allergies, medicines such as ACE inhibitors and anti-inflammatory drugs, thyroid-gland disorders, parasite infections and illnesses like lupus are some of the hidden causes of recurrent crops of hives. You have seen three specialists, all of whom ….. South Florida Sun-Sentinel (Fort Lauderdale, FL) – June 5, 2005 DR. PAUL DONOHUE GOOD HEALTH Dear Dr. Donohue: My 17-year-old son was just diagnosed with asthma. I am very confused by the medicines he takes. Would you please explain asthma medicines and how they’re used? — K. K. Dear K. K. : Asthma is a sudden constriction of airways together with an overproduction of mucus in those air passages. That makes it difficult to get air into and out of the lungs. An attack is much like being choked. I can simplify the concept of the two kinds of asthma medicines. One kind ….. (NY) – June 5, 2005 ASTHMA MEDICINES TAKE 2 DIFFERENT APPROACHES Dear Dr. Donohue: My 17-year-old son has just been diagnosed as having asthma. I am very confused by the medicines he takes. Would you please explain, in as simple terms as possible, asthma medicines and how they’re used? – K. K. Asthma is a sudden constriction of airways together with an overproduction of mucus in those air passages. That makes it difficult to get air into and out of the lungs. An attack is much like being choked. I can’t mention all asthma ….. – April 16, 2005 PHILADELPHIA — The recommendation that adults with mild asthma take medication every day to control the disease might be unnecessary, a new study suggests. Patients with mild persistent asthma who went without inhaled steroids or other daily medication had no more frequent asthma flare-ups than and had equally good lung function as patients who used the drugs. The study calls into question treatment guidelines issued in 1997 by a federal panel that recommend daily medication PHILADELPHIA — The recommendation that adults with mild asthma take medication every day to control the disease might be unnecessary, a new study suggests. Patients with mild persistent asthma who went without inhaled steroids or other daily medication had no more frequent asthma flare-ups than and had equally good lung function as patients who used the drugs. The study calls into question treatment guidelines issued in 1997 by a federal panel that recommend daily medication ….. Los Angeles Times (CA) – April 14, 2005 The Nation Adults With Mild Asthma Can Limit Drugs, Study Says About 4 million adult Americans with a mild form of asthma may not need to take daily steroid doses, but instead can use the drug only as needed to control symptoms, says a new study supported by the National Institutes of Health. The change would make drug use more convenient, minimize side effects from the powerful drugs and possibly save the nation as much as $2 billion per year, the study concludes. Its results do not apply to the 10 million adults with more severe forms of the …. – April 14, 2005 Asthma drug routine challenged Research suggests people with mild cases use medication when their symptoms flare up Doctors tell asthma patients to take their preventive medications daily, even if they feel fine. Physicians believe this routine can avert attacks and keep lungs healthier. But a new study challenges these widely accepted guidelines – at least for people with mild asthma. Research published in today’s New England Journal of Medicine found that people with mild, persistent asthma did very well simply by keeping their medications on hand and using the drugs only ….. (NY) – April 3, 2005 ALLERGIES MAY PLAY ROLE IN ASTHMA AT NIGHTTIME Dear Dr. Donohue: I have suffered from severe allergies and severe asthma since childhood. I take Advair, but it has had no noticeable effect on my nocturnal asthma, which is my main concern. Do you know any treatments that can ease nocturnal asthma? – D. R. Asthma is recurrent episodes of breathlessness, wheezing, chest tightness and coughing due to a sudden narrowing of the airways. Asthma attacks often strike during the night, and the reasons why aren’t clear. Your first ….. Birmingham Post, The (England) – February 16, 2005 The Birmingham Post: CULTURE: Amateur Stage: Is Ayckbourn losing his grip on English grammar? The one thing of which you can usually be certain in the shifting, unpredictable world of theatre is that another Alan Ayckbourn play is on the way. I don’t mean another via the local drama group, although it is hardly unusual to find one of them is about to offer its own account of something from the abundance of Ayckbourns at the disposal of amateurs. Indeed, Henley-in-Arden Dramatic Society opens with It Could Be Any One of Us tonight. No, I mean another – yet another, ….

361. – April 4, 2006 PREDNISONE ONLY ONE OF MANY ASTHMA DRUGS DEAR DR. DONOHUE: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her? — M. D. ANSWER: Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage of ….. Gazette, The (Cedar Rapids-Iowa City, IA) – April 4, 2006 Weight gain among side effects associated with prednisone Dear Dr. Donohue: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her? – M. D. Answer: Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage of air ….. (FL) – April 4, 2006 PREDNISONE ONLY ONE OF MANY ASTHMA DRUGS DEAR DR. DONOHUE: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her? — M. D. ANSWER: Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage of ….. – April 4, 2006 PREDNISONE ONLY ONE OF MANY ASTHMA DRUGS DEAR DR. DONOHUE: My wife has had asthma since 1998. She weighed 130 pounds then. She has been on prednisone for a few years, and her weight has gone up to 174 and it is all in her middle. Is there anything besides prednisone that would work for her? — M. D. ANSWER: Asthma makes people’s airways (bronchi) very sensitive to the slightest irritation. If they breathe things that wouldn’t bother the rest of us, their airways constrict, and that makes the passage of ….. – December 24, 2005 ASTHMA DOESN’T SIDELINE EASY ALAMEDA — These days, Omar Easy spends his Sundays chasing kick returners and trying to block punts for the Raiders’ special teams. When he was growing up in Saint Catherine, Jamaica, near the historic colonial site of Spanish Town, Sunday was all about church and soccer. Easy’s grandfather was a pastor, his grandmother a missionary, so it’s no surprise he spent every Sunday morning in church. The rest of the day was devoted to the first sport Easy knew ….. – December 24, 2005 ASTHMA DOESN’T SIDELINE EASY ALAMEDA — These days, Omar Easy spends his Sundays chasing kick returners and trying to block punts for the Raiders’ special teams. When he was growing up in Saint Catherine, Jamaica, near the historic colonial site of Spanish Town, Sunday was all about church and soccer. Easy’s grandfather was a pastor, his grandmother a missionary, so it’s no surprise he spent every Sunday morning in church. The rest of the day was devoted to the first sport Easy knew ….. wire (USA) – November 17, 2005 AstraZeneca Provides Additional Support to Hurricane Victims, Company launches relief efforts in partnership with Rotary Club of Houston to pledge additional support at AHA annual meeting PRNewswire-FirstCall — AstraZeneca (NYSE: AZN), one of the world’s leading pharmaceutical companies, announced today that it will provide an additional $125, 000 worth of critical supplies to hurricane victims. In partnership with the Rotary Club of Houston, AstraZeneca delivered two truckloads of critical supplies to El Centro de Corazon Health Clinic and El Spiritu de Salud Mobile Unit, which serve at-risk and underserved communities in the Houston area, including many families ….. – August 12, 2005 CAUSE OF CHRONIC HIVES OFTEN NOT FOUND DEAR DR. DONOHUE: I have had hives for almost three years. They pop up anywhere on my body. Sometimes my hands swell, too. I have seen a dermatologist, an allergist and a rheumatologist. Nothing has worked so far. Do you have any ideas? — D. F. ANSWER: Allergies, medicines such as ACE inhibitors and anti-inflammatory drugs, thyroid-gland disorders, parasite infections and illnesses like lupus are some of the hidden causes of recurrent crops of hives. You have seen three specialists, all ….. – August 12, 2005 CAUSE OF CHRONIC HIVES OFTEN NOT FOUND DEAR DR. DONOHUE: I have had hives for almost three years. They pop up anywhere on my body. Sometimes my hands swell, too. I have seen a dermatologist, an allergist and a rheumatologist. Nothing has worked so far. Do you have any ideas? — D. F. ANSWER: Allergies, medicines such as ACE inhibitors and anti-inflammatory drugs, thyroid-gland disorders, parasite infections and illnesses like lupus are some of the hidden causes of recurrent crops of hives. You have seen three specialists, all ….. (FL) – August 12, 2005 CAUSE OF CHRONIC HIVES OFTEN NOT FOUND DEAR DR. DONOHUE: I have had hives for almost three years. They pop up anywhere on my body. Sometimes my hands swell, too. I have seen a dermatologist, an allergist and a rheumatologist. Nothing has worked so far. Do you have any ideas? — D. F. ANSWER: Allergies, medicines such as ACE inhibitors and anti-inflammatory drugs, thyroid-gland disorders, parasite infections and illnesses like lupus are some of the hidden causes of recurrent crops of hives. You have seen three specialists, all ….

391. FD (FAIR DISCLOSURE) WIRE – April 30, 2003 Q1 2003 AstraZeneca PLC Earnings Conference Call – Final OPERATOR: Good day ladies and gentlemen and welcome to the AstraZeneca Q1 Results Conference Call. This call is being recorded. Today’s Question and Answer Session will be conducted electronically. If you would like to ask a question, please press the star or asterix key, followed by the digit ‘1′ on your touchtone phone. At this time I would like to turn the call over Mr. Ed Seage (ph) with AstraZeneca. Please go ahead sir. ED SEAGE, IR, ASTRAZENECA …. 2. – December 6, 2002 Cops 08 Births Hospitals release the names of only those patients who sign consent forms. Great River Medical Center Dec. 3 Jim and Julie Belger, Burlington, girl Arrests/citations Reports are taken directly from the daily logs of area law enforcement agencies. Some agencies do not differentiate between arrests and citations. Burlington Saturday 3:28 a. m. Riverfront at south railroad bridge. Bradley Smyth, 29, 812 Emmett St. : open burning. 2:46 a. m. 222 Hayes Court ….. 3. – October 17, 2002 BREATHMOBILE, BETTER MEDICATIONS BRING KIDS HOPE OF A NORMAL LIFE As a child, Margaret Huggins spent many afternoons by the living-room window, feeling as fragile as the pane of glass through which she gazed. She would have been on the other side of that window, joining her friends in games of tag or hide-and-seek, if not for her asthma, a disease that would steal her breath away when she wasn’t careful. Huggins, 32, remembers those days even now as she looks out another living-room window, this time to watch her 13-year-old daughter, …. 4. Herbert River Express (Australia) – October 8, 2002 Asthma is no joke IT’S often been said that laughter is the best medicine. But when it comes to the treatment of asthma that may not always be the case. In fact laughing may be counter productive for children with asthma. A University of NSW study published earlier this year showed that the physical action of laughing (not the emotion of mirth) could sometimes trigger an attack. However, there’s no need to take the fun out of your child’s life. The good news, according …. 5. (CA) – September 4, 2002 How to treat asthma Dear Dr. Gott: My son, 31, has suffered from asthma for years. He’s happily married and enjoys his pets, plants and dried flower arrangements — all of which aggravate his condition. Just how serious is this for his well-being? Dear Reader: It could be quite serious. Although I understand your concern about your son’s health, only he can choose which steps he can take to improve it. For some asthma patients, the disease is a life-threatening handicap requiring aggressive …. 6. (CA) – September 4, 2002 How to treat asthma Dear Dr. Gott: My son, 31, has suffered from asthma for years. He’s happily married and enjoys his pets, plants and dried flower arrangements — all of which aggravate his condition. Just how serious is this for his well-being? Dear Reader: It could be quite serious. Although I understand your concern about your son’s health, only he can choose which steps he can take to improve it. For some asthma patients, the disease is a life-threatening handicap requiring aggressive …. 7. – September 4, 2002 How to treat asthma Dear Dr. Gott: My son, 31, has suffered from asthma for years. He’s happily married and enjoys his pets, plants and dried flower arrangements — all of which aggravate his condition. Just how serious is this for his well-being? Dear Reader: It could be quite serious. Although I understand your concern about your son’s health, only he can choose which steps he can take to improve it. For some asthma patients, the disease is a life-threatening handicap requiring aggressive …. 8. – September 4, 2002 How to treat asthma Dear Dr. Gott: My son, 31, has suffered from asthma for years. He’s happily married and enjoys his pets, plants and dried flower arrangements — all of which aggravate his condition. Just how serious is this for his well-being? Dear Reader: It could be quite serious. Although I understand your concern about your son’s health, only he can choose which steps he can take to improve it. For some asthma patients, the disease is a life-threatening handicap requiring aggressive …. 9. – September 4, 2002 How to treat asthma Dear Dr. Gott: My son, 31, has suffered from asthma for years. He’s happily married and enjoys his pets, plants and dried flower arrangements — all of which aggravate his condition. Just how serious is this for his well-being? Dear Reader: It could be quite serious. Although I understand your concern about your son’s health, only he can choose which steps he can take to improve it. For some asthma patients, the disease is a life-threatening handicap requiring aggressive ….. (FL) – May 18, 2002 EXERCISE-FREE METHOD OF BUILDING MUSCLE IN THE WORKS Wouldn’t it be nice to spend your evenings watching TV or reading and still build fit muscles? That fantasy may one day be a reality, thanks to the recent discovery in animal studies that muscle fibers can be transformed without exercise into the oxygen-burning, energizing type that are the pride of marathon runners. For about 10 years, scientists have been studying the chemical signals that turn muscle fibers that tire easily into fatigue-resistant ones. One signal that ….