Asthma treatment

71. Mobile Register (AL) – January 18, 2000 Too much drug info may be confusing Too much drug info may be confusing By ADRIENNE MCGEE The Lima News Allegra, Claritin, Zyrtec, Zyban, Accolate, Zomig. These once strange-sounding names are now common, with the stream of advertisements promoting prescription drugs by name and the Internet offering easy access to information. This can have its good points and bad, physicians say. From patients coming in to doctors’ offices and asking for a particular drug by name to being frightened of a drug because of ….. Financial Times (London, England) – March 29, 1996 Shorts: FDA panel deals blow to Zeneca Pharmaceuticals, Pharmaceuticals. Zeneca, the drugs group, suffered a serious blow when a panel of advisers to the US Food and Drug Administration voted against approving Accolate, an asthma treatment tipped as one of the company’s most important new products. Page 29 ….. – January 19, 2001 Features DEAR DR. DONOHUE: I am a 42-year-old female diagnosed with asthma four months ago. My problem was shortness of breath, not wheezing. My doctor prescribed Accolate and two inhaled medicines — Serevent and Flovent. I still suffer from shortness of breath. I always thought asthma was a childhood condition. At age 22 I had thyroid cancer. The cancer was removed, and I received radiation therapy. I am also a former smoker. Could my shortness of breath be something other than asthma? — ….. (TX) – January 19, 2001 Asthma attacks adults as well as children DEAR DR. DONOHUE: I am a 42-year-old female diagnosed with asthma four months ago. My problem was shortness of breath, not wheezing. My doctor prescribed Accolate and two inhaled medicines – Serevent and Flovent. I still suffer from shortness of breath. I always thought asthma was a childhood condition. At age 22 I had thyroid cancer. The cancer was removed, and I received radiation therapy. I am also a former smoker. Could my shortness of breath be something other than asthma? — ….. – January 19, 2001 DR. PAUL DONOHUE Dear Dr. Donohue: I am a 42-year-old female diagnosed with asthma four months ago. My problem was shortness of breath, not wheezing. My doctor prescribed Accolate and two inhaled medicines – Serevent and Flovent. I still suffer from shortness of breath. At age 22 I had thyroid cancer. The cancer was removed, and I received radiation therapy. I am also a former smoker. Could my shortness of breath be something other than asthma? The onset of asthma has two peaks. One occurs between ….. Sun-Sentinel – January 19, 2001 LUNG TESTS PINPOINT CAUSE OF BREATHING ILLS Dear Dr. Donohue: I am a 42-year-old female diagnosed with asthma four months ago. My problem was shortness of breath, not wheezing. My doctor prescribed Accolate and two inhaled medicines — Serevent and Flovent. I still suffer from shortness of breath. I always thought asthma was a childhood condition. At age 22 I had thyroid cancer. The cancer was removed, and I received radiation therapy. I am also a former smoker. Could my shortness of breath be something other than asthma? — C. M ….. . (MI) – January 19, 2001 Asthma can attack adults as well as kids Dear Dr. Donohue: I am a 42-year-old female diagnosed with asthma four months ago. My problem was shortness of breath, not wheezing. My doctor prescribed Accolate and two inhaled medicines — Serevent and Flovent. I still suffer from shortness of breath. I always thought asthma was a childhood condition. At age 22, I had thyroid cancer. The cancer was removed, and I received radiation therapy. I am also a former smoker. Could my shortness of breath be something other than asthma? ….. (NY) – January 19, 2001 ASTHMA ALSO HITS ADULTS Dear Dr. Donohue: I am a 42-year- old female diagnosed with asthma four months ago. My problem was shortness of breath, not wheezing. My doctor prescribed Accolate and two inhaled medicines, Serevent and Flovent. I still suffer from shortness of breath. I always thought asthma was a childhood condition. At age 22 I had thyroid cancer. The cancer was removed, and I received radiation therapy. I am also a former smoker. Could my shortness of breath be something other than asthma? – ….. Daily Hampshire Gazette (Northampton, MA) – May 9, 2000 Cat got your lungs? Love your cat. . . but not the way you wheeze when she gets close? Cat allergies affect between 5 and 10 percent of the population. There may be some good news. Researchers at Johns Hopkins University in Baltimore have found that a relatively new type of asthma drug can provide some relief when you get too close to kitty. Zaflirlukast, marketed as Accolate, blocks chemicals released in the lungs that can cause asthma symptoms. The researchers asked 18 volunteers with cat-induced asthma ….. The Gazette (Cedar Rapids-Iowa City) – January 19, 2001 Woman diagnosed with asthma should get 2nd opinion Dear Dr. Donohue: I am a 42-year-old female who was diagnosed with asthma four months ago. My problem was shortness of breath, not wheezing. My doctor prescribed Accolate and two inhaled medicines – Serevent and Flovent. I still suffer from shortness of breath. I always thought asthma was a childhood condition. At age 22 I had thyroid cancer. The cancer was removed, and I received radiation therapy. I am also a former smoker. Could my shortness of breath be something other than asthma? – ….

81. Times Union, The (Albany, NY) – November 4, 2003 SOME DRUGS HELP OTHER SYMPTOMS BY SUZY COHEN, R. PH. Q: I take Singulair for asthma and it seems to help, though what I notice the most is that my allergies have gotten dramatically better. Is it for both? — N. S. , Birmingham, Ala. A: There is science behind the fact that drugs like Singulair help allergies, but they are only FDA-approved for asthma and are often prescribed along with inhaled steroids. Drugs like Singulair, including Accolate and Zyflo, are all known as leukotriene inhibitors (pronounced luke-o-try-ene). They are called this ….. Hamilton Spectator, The (Ontario, Canada) – May 31, 2000 Cat allergy cured by asthma drug A new drug to treat asthma also seems to be the cat’s meow for symptoms of feline allergies. While successfully treating asthma in adults and children, zafirlukast, known by the brand name Accolate, also prevents the wheezing, shortness of breath and itchy, runny noses triggered by allergens in cat dander, say researchers at Johns Hopkins Medical Center in Baltimore. The researchers tested 18 people with cat allergies, randomly giving them either the drug or a placebo for a ….. Chemical Business NewsBase: Company Reports – CBNB (United Kingdom) – July 30, 2009 Chemical Business NewsBase – Company Reports – CBNB: AstraZeneca 2Q and 1H 2009: Respiratory and Inflammation sales. AstraZeneca reported 2Q 2009 sales of $7958 M (2Q 2008: $7956 M). Sales by the Respiratory and Inflammation division totalled $997 M (2Q 2008: $1078 M), with sales of Symbicort at $551 M (2Q 2008: $518 M), Pulmicort at $311 M (2Q 2008: $383 M); Rhinocort at $72 M (2Q 2008: $92 M), Oxis at $16 M (2Q 2008: $21 M) and Accolate at $16 M (2Q 2008: $19 M). Symbicort sales in the US were $111 M, a 95% increase over last year (at constant exchange rates). Growth is being fuelled by continued ….. Times, The (London, England) – July 22, 1999 Breathe easy, the family pet can stay, Body and Mind Kim, an aged but friendly labrador, is now too stiff and arthritic to accompany his master out shooting, but he thoroughly enjoys life. Kim, who wags his tail with huge enthusiasm whenever he greets his family, is unaware how they were planning the final treachery – to put him down. This was not entirely because of Kim’s age but because of the moderately severe but uncontrolled asthma suffered by the 15-year-old son of the house. Kim’s life was saved, and the ….. (CA) – June 15, 1997 NEW DRUG MAY HELP ASTHMA SUFFERERS After a research effort that goes back nearly 40 years, scientists at Harvard University have seen their work developed into a new drug that could help millions of people who suffer from asthma. K. Frank Austen, a Harvard professor of medicine who has been involved since the research began in 1959, said the new drug, called Accolate, is the first ever developed that treats the causes of asthma and not just the symptoms. ”Older drugs relax smooth muscles and open ….. Chemical Business NewsBase: Company Reports – CBNB (United Kingdom) – October 27, 2008 Chemical Business NewsBase – Company Reports – CBNB: AstraZeneca 1Q 2008: Sales of Respiratory and Inflammation drugs. For 1Q 2008, AstraZeneca reported sales of $1040 M for Respiratory and Inflammation drugs, 5% more than for 1Q 2007, at CER. These comprised Symbicort ($471 M, +21%); Pulmicort ($411 M, -1%); Rhinocort ($80 M, -16%); Oxis ($17 M, -35%) and Accolate ($18 M, -5%). Symbicort sales in the US were $44 M. Overall, Symbicort’s share of new prescriptions for fixed combinations reached 7. 8% in the week ending 11 Apr 2008; market share among patients newly starting combination treatments has ….. – May 31, 2000 HOTLINE HELPS MOMS-TO-BE JUDGE RISKS It was a choice Annette Coleman was forced to make: Breathe or have a healthy baby. The 36-year-old Tucson secretary, about four months pregnant with her second child, was told by her physician to think about going off Accolate, a drug that treats chronic asthma. Concerned about possible birth defects, Coleman did so. Two days later, her wheezing out of control, she called her doctor’s office and pleaded for help. They gave her the number for a pregnancy risk hotline ….. Chemical Business NewsBase: Company Reports – CBNB (United Kingdom) – January 22, 2009 Chemical Business NewsBase – Company Reports – CBNB: AstraZeneca 3Q and Jan-Sep 2008: Respiratory and Inflammation sales. 3Q 2008 sales of AstraZeneca’s Respiratory and Inflammation treatments amounted to $951 M (+10%, CER terms). Sales for Jan-Sep 2008 totalled $3069 M (+8%). Key sales data are tabulated for Symbicort ($501 M for 3Q 2008), Pulmicort ($304 M), Rhinocort ($72 M), Accolate ($18 M) and Oxis ($18 M). Symbicort sales in the US were $64 M in 3Q 2008. Symbicort sales in other markets were $437 M, 9% ahead of 3Q 2007 on a 6% increase in Western Europe and a 19% increase in Emerging Markets. US ….. Daily Hampshire Gazette (Northampton, MA) – June 10, 1997 GOING AFTER ASTHMA NEW DRUG TAKES AIM AT DISEASE’S CAUSES Third Age News Service After a research effort that goes back nearly 40 years, scientists at Harvard University have seen their work developed into a new drug that could help millions of people who suffer from asthma. K. Frank Austen, a Harvard professor of medicine who has been involved since the research began in 1959, said the new drug, called Accolate, is the first ever developed that treats the causes of asthma and not just the symptoms. “Older drugs relax smooth muscles and …. 0. New York Times, The (NY) – June 13, 2009 F. D. A. Calls For a Caution On Label of Merck Drug Merck & Company’s top-selling drug, the asthma medication Singulair, and similar medicines should come with a caution about reports of psychiatric problems in some patients, the Food and Drug Administration said. The F. D. A. requested a precaution in the prescribing instructions for Singulair, Accolate from AstraZeneca and Zyflo and Zyflo CR from Cornerstone Therapeutics. A precaution is a less serious alert than a warning. Problems reported include agitation, suicide, ….

91. Toronto (Ontario, Canada) – August 9, 2002 The case for strong patent protection in Canada Murray J. Elston CANADA’S RESEARCH-Based Pharmaceutical Companies (Rx&D) invest heavily in the research and development of new medicines that treat and cure a range of diseases. In recent years, advances have included Heptovir, a new medication for the treatment of chronic hepatitis-B; Accolate, the first medication in a new class of drugs to fight asthma; and Aricept a breakthrough medication that improves memory and attention functions in …. 2. KNIGHT RIDDER/TRIBUNE BUSINESS NEWS – September 21, 1999 DAILY MAIL, LONDON, MARKET REPORT Sep. 21–JAB FOR DRUG FIRMS AS BUYERS PERK UP: Drug shares are looking much healthier. Buyers are sniffing around again, attracted to the defensive and growth merits of the sector which comes into its own when cyclicals disappoint. There is also the continued prospect of further consolidation in a global industry where the larger players each control under 5 percent of the market, Astra Zeneca zoomed 58 pence to 2558 pence for a two-day jump of 115 pence. Accolate, its novel mini-tablet …. Times, The (London, England) – July 25, 1997 Zeneca’s drug forecast, Business Roundup ZENECA, the pharmaceuticals group, said it does not expect fresh difficulties securing further regulatory approvals for its new asthma drug, in spite of health problems that some US users have suffered. Zeneca has told US doctors that a “handful” of the 250, 000 to 300, 000 Americans on Accolate tablets have had symptoms including breathing difficulties and heart problems. Zeneca suggests they may arise because severe asthma sufferers cut their intake of other …. 4. , The (FL) – March 28, 2008 FDA probes allergy drug, suicide link WASHINGTON — The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S. , according to Merck. First approved in 1998, it’s part of a class …. 5. – June 21, 2000 Drug may improve cat allergies For the 5 percent to 10 percent of the population that suffers from cat allergies, there may be some good news. Researchers at Johns Hopkins University have found that a relatively new type of drug can provide some relief when you get too close to kitty. Zaflirlukast, marketed as Accolate, blocks chemicals released in the lungs that can cause asthma symptoms. The researchers asked 18 volunteers with cat-induced asthma to spend one hour in a special “cat challenge …. 6. – May 10, 2000 RX: CAT GOT YOUR LUNGS? There may be some good news for those who start to wheeze when the family cat is around. Researchers at Johns Hopkins University in Baltimore have found that a relatively new type of asthma drug can provide some relief when you get too close to kitty. Zaflirlukast, marketed as Accolate, blocks chemicals released in the lungs that can cause asthma symptoms. The drug is available by prescription. …. 7. (MO) – March 28, 2008 FDA investigates Singulair-suicide link The inquiry is based on reports, not studies; none of 11, 000 patients in 40 drug trials has committed suicide. The Food and Drug Administration said Thursday that it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a class of …. 8. (TX) – March 28, 2008 FDA investigating possible link between Merck’s Singulair allergy drug and suicide WASHINGTON (AP) _ The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a …. 9. (TX) – March 28, 2008 FDA investigating possible link between Merck’s Singulair allergy drug and suicide WASHINGTON (AP) _ The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a ….. (CA) – March 28, 2008 Allergy drug could be linked to suicide WASHINGTON — The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, ….

101. San Mateo Daily Journal, The (CA) – March 28, 2008 FDA investigating possible link between Merck’s Singulair allergy drug and suicidal behaviour WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a ….. – March 28, 2008 FDA investigates possible link between allergy drug, suicide Inquiry is driven by symptom reports, not clinical studies. WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a ….. (USA) – March 28, 2008 FDA Investigates Possible Link Between Merck’s Singulair Allergy Drug, Suicide March 28, 2008 ( ) The Food and Drug Administration said it is investigating a possible link between Merck & Co. ’s (NYSE: MRK) best-selling Singulair and suicide. Singulair was first approved in 1998 and is part of a class of asthma and allergy drugs that includes AstraZeneca’s (NYSE: AZN) Accolate and Critical Therapeutics’s (NASDAQ: CRTX) Zyflo. FDA said it is reviewing reports of mood changes, suicidal behavior ….. – October 24, 2004 It’s a long, bumpy road for finding a new drug, For one 34-year veteran, there was 1 Ôblockbuster’ By TED GRIFFITH The News Journal For 34 years, Cyrus Ohnmacht has been showing up for work in Fairfax knowing that the odds are overwhelmingly against him. The pharmaceutical chemist for AstraZeneca spends part of his days in a laboratory, crowded with test tubes and bottles of chemical reagents, trying to find experimental compounds that might one day become new medicines. It’s often a fruitless quest. Ohnmacht and hundreds of other scientists at AstraZeneca test ….. Guardian, The (London, England) – February 1, 2003 The Guardian: Jobs & Money: Company vitae: AstraZeneca: Which this week announced profits of pounds 2. 7bn, valuing it at more than pounds 34bn A new business in Adland? Not quite, but it has a heavyweight advertising budget. AstraZeneca is one of the world’s top five pharmaceutical companies manufacturing cancer treatments, that includes Nolvadex for the treatment of breast cancer and Zoladex to treat prostate cancer. Other remedies run the gamut from asthma reliever Accolate to migraine treatment Zomig. Isn’t that a double helix I see before me? Double what? Take a closer look, that’s a ….. Times, The (London, England) – March 12, 1997 Zeneca expands US salesforce as profits top Pounds 1bn ZENECA, the pharmaceuticals group, will this year expand its US salesforce from 1, 200 to nearly 2, 000 to support the launch of its strong portfolio of new drugs in the largest healthcare market. The rapidly rising sales of new drugs such as Casodex (for prostate cancer), Arimidex (breast cancer) and Accolate (asthma) was again a key feature of Zeneca’s full-year results yesterday. Zeneca said products launched within the last two years were responsible for 40 per cent of the ….. Toronto (Ontario, Canada) – May 12, 2000 Cat got your lungs? Cat allergies affect between 5 and 10 per cent of the population, but researchers at Johns Hopkins University in Baltimore report that Accolate, a prescription asthma drug, can provide some relief. Eighteen volunteers with cat-induced asthma spent one hour in a special “cat challenge room, ” a carpeted room that was home to several cats and which provided 10 to 100 times the usual level of cat allergens. Bedding in the room was shaken just before each volunteer went ….. Times, The (Trenton, NJ) – February 24, 1999 New asthma medicines a breath of fresh air DEAR DR. GOTT: I have asthma. For the past year, I have had frequent attacks that are only partially relieved by inhalers. I am reluctant to use steroids. Now my doctor proposes a new drug called a leukotriene modifier. What’s the story? Is it safe? DEAR READER: Asthma attacks are often caused by inflammation of the bronchial lining. Leukotrienes are potent substances in the body that worsen this inflammation and contribute to increased mucus production. Researchers have long ….. (FL) – February 20, 1999 New asthma medicines are available DEAR DR. GOTT: I have asthma. For the past year, I have had frequent attacks that are only partially relieved by inhalers. I am reluctant to use steroids. Now my doctor proposes a new drug called a leukotriene modifier. What’s the story? Is it safe? DEAR READER: Asthma attacks are often caused by inflammation of the bronchial lining. Leukotrienes are potent substances in the body that worsen this inflammation and contribute to increased mucus production. Researchers have ….. Stuart News, The (FL) – February 20, 1999 NEW MEDICINES FOR ASTHMA ARE AVAILABLE DEAR DR. GOTT: I have asthma. For the past year, I have had frequent attacks that are only partially relieved by inhalers. I am reluctant to use steroids. Now my doctor proposes a new drug called a leukotriene modifier. What’s the story? Is it safe? DEAR READER: Asthma attacks are often caused by inflammation of the bronchial lining. Leukotrienes are potent substances in the body that worsen this inflammation and contribute to increased mucus production. Researchers have long ….

111. – February 20, 1999 NEW DRUGS AID ASTHMA PATIENTS BUT MAY RESULT IN SIDE EFFECTS DEAR DR. GOTT: I have asthma. For the past year, I have had frequent attacks that are only partially relieved by inhalers. I am reluctant to use steroids. Now my doctor proposes a new drug called a leukotriene modifier. What’s the story? Is it safe? Asthma attacks are often caused by inflammation of the bronchial lining. Leukotrienes are potent substances in the body that worsen this inflammation and contribute to increased mucus production. Researchers have long worked to ….. Advertiser, The (Adelaide, Australia) – January 25, 1999 Wide-ranging new drugs approved for use TWO pills to help prevent asthma attacks were among 36 new drug treatments approved in Australia in 1998. Singulair and Accolate, made by different drug companies, have undergone trials worldwide. Doctors say the daily pills should be used as an additional treatment to inhaled preventer steroids. The Australian Pharmaceutical Manufacturers Association has released details of drugs approved by the Therapeutic Goods Administration last year. The 36 treatments will ….. M2 Presswire – June 15, 2009 US Food & Drug Administration: FDA Requests Labeling Change for Leukotriene Modifiers The U. S. Food and Drug Administration today provided further updated safety information on a class of asthma drugs known as leukotriene modifiers. The FDA has requested that manufacturers include a precaution in the drug prescribing information (drug labeling) regarding neuropsychiatric events (behavior, mood changes) that have been reported in some persons taking montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo and Zyflo CR). Leukotrienes are chemicals the body ….. Chemical Business NewsBase: Company Reports – CBNB (United Kingdom) – January 29, 2009 Chemical Business NewsBase – Company Reports – CBNB: AstraZeneca 4Q and full year 2008: respiratory and inflammation sales. 4Q 2008 sales of AstraZeneca’s Respiratory and Inflammation products totalled $1059 M at constant exchange rates (CER), 6% more than for 4Q 2007. Full year 2008 sales rose by 7% to $4128 M. Sales data are tabulated for Symbicort (4Q 2008 sales of $514 M, +29%); Pulmicort ($397 M, -10%); Rhinocort ($78 M, -8%); Accolate ($18 M, -5%) and Oxis ($15 M, -27%). Symbicort sales in the US were $90 M in 4Q 2008 and $255 M for the full year. Symbicort sales in other markets in 4Q 2008 were ….. Montgomery Advertiser (AL) – November 27, 2005 Bottomline Nickel joins council board Realtor Sandra Nickel has been selected as a board member of the Council of Residential Specialists. Nickel will also serve as one of two at-large members on the councils six-person executive committee. Nickel has been a frequent speaker at National Association of Realtors events around the U. S. She has been in the real estate business for 25 years. She is active in historic preservation, neighborhood enhancements and economic development. She is a graduate of ….. – February 20, 1999 NEW ASTHMA MEDICINES ARE AVAILABLE Q: I have asthma. For the past year, I have had frequent attacks that are only partially relieved by inhalers. I am reluctant to use steroids. Now my doctor proposes a new drug called a leukotriene modifier. What’s the story? Is it safe? A: Asthma attacks are often caused by inflammation of the bronchial lining. Leukotrienes are potent substances in the body that worsen this inflammation and contribute to increased mucus production. Researchers have long ….. Chemical Business NewsBase: US Food and Drug Administration News (United Kingdom) – June 12, 2009 Chemical Business NewsBase – US Food and Drug Administration News: FDA requests labelling change for leukotriene modifiers. On 12 Jun 2009, the US Food and Drug Administration provided further updated safety information on a class of asthma drugs known as leukotriene modifiers. The FDA has requested that manufacturers include a precaution in the drug prescribing information (drug labeling) regarding neuropsychiatric events (behavior, mood changes) that have been reported in some persons taking montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo and Zyflo CR). Leukotrienes are chemicals the body ….. – January 19, 2001 Asthma Afflicts Adults as Well as Children Dear Dr. Donohue: I am a 42-year-old female diagnosed with asthma four months ago. My problem was shortness of breath, not wheezing. My doctor prescribed Accolate and two inhaled medicines — Serevent and Flovent. I still suffer from shortness of breath. I always thought asthma was a childhood condition. At age 22 I had thyroid cancer. The cancer was removed, and I received radiation therapy. I am also a former smoker. Could my shortness of breath be something other than asthma? — ….. Daily Telegraph (Sydney, Australia) – February 16, 1998 ASTHMA LIFELINE A new asthma pill which was launched in Britain this week and is being considered for release in Australia could drastically reduce the number of asthma attacks suffered by many children and adults. Singulair is one of a family of drugs called leukotriene antagonists which have been on the US market for a year under the brand name Accolate. If given the go-ahead by the Therapeutic Goods Administration, Singulair could be widely available in Australia next year. “It is a very ….. – April 27, 2000 SEE UROLOGIST ABOUT VEIN REMOVAL Q: After a vasectomy, I developed what my doctor diagnosed as a varicose vein in my penis. It’s constantly uncomfortable and makes intercourse painful. Should I have my vasectomy reversed? A: A swollen penile vein would be an extremely rare consequence of vasectomy, because the operation is carried out in the scrotum and does not ordinarily affect the penile veins. Therefore, I doubt that reversal of your vasectomy — in itself, a technically challenging procedure — ….

121. Stuart News, The (FL) – April 27, 2000 A UROLOGIST CAN ADDRESS VEIN REMOVAL DEAR DR. GOTT: After a vasectomy, I developed what my doctor diagnosed as a varicose vein in my penis. It’s constantly uncomfortable and makes intercourse painful. Should I have my vasectomy reversed? DEAR READER: A swollen penile vein would be an extremely rare consequence of vasectomy, because the operation is carried out in the scrotum and does not ordinarily affect the penile veins. Therefore, I doubt that reversal of your vasectomy – in itself, a technically challenging ….. Knoxville News Sentinel (TN) – March 28, 2008 FDA investigating link between Singulair, suicide WASHINGTON — The Food and DrugAdministrationsaidThursday it is investigating a possible linkbetweenMerck’sbest-selling Singulair and suicide. FDAsaiditisreviewingahandful of reports involving mood changes, suicidal behavior and suicideinpatientswhohavetaken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulairisusedbymillions ofpatientsintheUnitedStates, according to Merck. First approved in 1998, it’s part of a class of ….. – June 18, 2000 New asthma drug provides relief for cat lovers Love your cat but not the way you wheeze when she gets close? Cat allergies affect between 5 and 10 percent of the population. There may be some good news. Researchers at Johns Hopkins University in Baltimore have found that a relatively new type of asthma drug can provide some relief when you get too close to kitty. Zaflirlukast, marketed as Accolate, blocks chemicals released in the lungs that can cause asthma symptoms. The researchers asked 18 volunteers with cat-induced asthma …. Sun-Sentinel – May 14, 2000 CAT ALLERGY HELP Love your cat — but not the way you wheeze when she gets close? Cat allergies affect between 5 and 10 percent of the population. There may be some good news. Researchers at Johns Hopkins University in Baltimore have found that a relatively new type of asthma drug can provide some relief when you get too close to kitty. Zaflirlukast, marketed as Accolate, blocks chemicals released in the lungs that can cause asthma symptoms. The researchers asked 18 volunteers with cat-induced asthma to ….. (NJ) – May 7, 2000 CAT GOT YOUR LUNGS? NEW DRUG MAY PROVIDE RELIEF Love your cat, but not the way you wheeze when she gets close? Cat allergies affect between 5 and 10 percent of the population. There may be some good news. Researchers at Johns Hopkins University in Baltimore have found that a relatively new type of asthma drug can provide some relief when you get too close to kitty. Zaflirlukast, marketed as Accolate, blocks chemicals released in the lungs that can cause asthma symptoms. The researchers asked 18 volunteers with cat-induced asthma to …. Times, The (London, England) – January 9, 1997 Zeneca cool on acquisitions, Business Roundup ZENECA GROUP, the UK pharmaceuticals company at the centre of persistent takeover speculation, said yesterday that it saw no need for strategic acquisitions, and had yet to come across any takeover opportunities that offered both “value and quality”. In a final interview before the company enters its closed reporting period, David Barnes, chief executive, said: “I am not against acquisitions per se, but they have to offer value and quality, and most ….. (Sheffield, England) – March 8, 2007 The Star (Sheffield): Helen ‘fully deserves’ top award HELEN O’Brien has been named Sheffield Young Accountant of the Year. Helen, who specialises in audit and accountancy services to limited companies and works for UHY Wingfield r, received the accolate at the annual awards ceremony held by the Sheffield and District Society of Chartered Accountants. She joined the Wellington Street practice as a trainee in 2002 after a spell as a manager with Skipton Building Society. Later this year she will take her final ….. – May 15, 2000 New medication may help those with cat allergies Love your cat, but not the way you wheeze when she gets close? Cat allergies affect between 5 and 10 percent of the population. There may be some good news. Researchers at Johns Hopkins University in Baltimore have found that a relatively new type of asthma drug can provide some relief when you get too close to kitty. Zaflirlukast, marketed as Accolate, blocks chemicals released in the lungs that can cause asthma symptoms. The researchers asked 18 volunteers with cat-induced asthma ….. (Riverside, CA) – November 16, 1999 Progress is slow in treating asthma Despite the rise in asthma cases, new treatments have been slow in coming. For example, within the past two years, three new drugs have been released to treat migraines, with another due in the spring. But for asthma, which accounts for more pediatric hospitalizations each year than any other illness, only two significant drugs were approved: Accolate by Astra-Zeneca and Singulair from Merck. These drugs, taken as pills, address the chief problem with asthma treatments: the sheer ….. Newstex Blogs (USA) – July 4, 2009 Popular Asthma Medicine Singulair Associated With Psychiatric Disorders In Children Jul. 4, 2009 ( Drug Injury Watch delivered by Newstex) New Medical Journal Article Follows June 2009 FDA-Required Warning For Singulair About Neuropsychiatric Events (Posted by Tom Lamb at DrugInjuryWatch. com) On June 12, 2009 the FDA announced a new warning about an increased risk of neuropsychiatric events for the asthma medicine Singulair (montelukast)– as well as some other less popular leukotriene inhibitors, Accolate (zafirlukast) as well as Zyflo and ….

141. Mobile Register (AL) – May 4, 2000 New drug may ease cat allergy New drug may ease cat allergy The Washington Post Love your cat …. but not the way you wheeze when she gets close? Cat allergies affect between 5 and 10 percent of the population. There may be some good news. Researchers at Johns Hopkins University in Baltimore have found that a relatively new type of asthma drug can provide some relief when you get too close to kitty. Zaflirlukast, marketed as Accolate, blocks chemicals released in the lungs that can cause asthma symptoms. The researchers ….. wire (USA) – February 23, 2006 SecurStar Wins International Security Award 2006, Awarded in Best Disk Encryption, Best Email Security Solution, and Best Desktop Firewall Categories PRNewswire — SecurStar GmbH with headquarter in Germany announced that the company’s products have gained SC Magazine Awards 2006. SecurStar’s encryption solutions have convinced readers as well as jury in all categories in which the company competed (best disk encryption, best email security solution, and best desktop firewall). With more than 1, 300 nominated products and solutions from 330 global companies, the SC Magazine Awards belong to the internationally most …. Chicago Tribune – November 2, 2003 A few ways to battle allergies Q. I take Singulair for asthma and it seems to help, though what I notice the most is that my allergies have gotten dramatically better. Is it for both? –N. S. , Birmingham, Ala. A. There is science behind the fact that drugs such as Singulair help allergies, but they are FDA-approved only for asthma and are often prescribed along with inhaled steroids. Drugs like Singulair, including Accolate and Zyflo, are all known as leukotriene inhibitors (pronounced ….. – January 14, 2009 No evidence yet of Singulair suicide risk The U. S. Food and Drug Administration said a safety review has yet to find conclusive evidence of any link between certain asthma drugs and suicide. The agency last March announced that it was reviewing data that raised concerns about a possible association between the use of Singulair and behavior/mood changes, suicide, suicidal thinking and suicidal behavior. The FDA has urged both healthcare professionals and patients to report side effects from the use of drugs Singulair, ….. Altus Times (OK) – July 19, 2007 Altus woman encourages all to donate organs ALTUS – Altus resident Connie Conner would like us to celebrate the miracle that is her daughter’s life and to encourage us, especially Hispanics among us, to donate our organs so that others may live. On March 9 of this year, Cecilia Page, 32, of Spring Hill, Fla. , received a liver from a 20-year-old Puerto Rican man who had been killed in a traffic accident in Puerto Rico. He had Page’s blood type, fit her height and weight and was listed on his ….. Guardian, The (London, England) – June 28, 2003 The Guardian: Rise: Inside track: AstraZeneca: A 60-second cribsheet on some of the country’s largest employers of graduates What does it do? AstraZeneca is one of the top five pharmaceutical companies manufacturing cancer treatments that include Nolvadex for the treatment of breast cancer and Zoladex to treat prostate cancer. Other remedies run the gamut from asthma reliever Accolate to migraine treatment Zomig. The company’s drugs are focused on seven important areas of medical need including cancer and cardiovascular and gastrointestinal disorders. What does it want from me? To start a ….. The San Diego Union-Tribune – February 24, 1998 The Day’s Big Movers NEW YORK — Some of the stocks that moved substantially or traded heavily yesterday: NYSE Merck, up 5 15/16 at 130 5/8 The Food and Drug Administration cleared the drugmaker to begin selling its Singulair asthma drug next month. Singulair is one of a new class of oral asthma drugs that target the causes of the disease, rather than symptoms. The first such drug to win FDA approval was Zeneca Group’s Accolate. Magna Group, up 10 9/16 at 57 1/2 Union Planters, a bank ….. – March 28, 2008 FDA probing possible link between allergy drug and suicide The Food and Drug Administration said Thursday that it is investigating a possible link between Merck’s best-selling Singulair and a few reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3billion last year, Singulair is used by millions of patients in the U. S. , according to Merck. First approved in 1998, it’s part of a class of asthma and allergy drugs that includes ….. New Hamburg Independent (Ontario, Canada) – September 15, 2004 Brand-name revenue helps develop new drugs I read with interest the article by CPGA president Jim Keon (Brand vs. Generic, August 11). The member companies of Canada’s Research-Based Pharmaceutical Companies (Rx and D) invest heavily in the research and development (R and D) of new medicines that treat and cure a range of diseases. In 2003, Rx and D member companies invested over $1 billion in R and D. In recent years, advances have included Heptovir, a new medication for the treatment of chronic hepatitis-B; ….. The Cincinnati Post – December 4, 1998 Asthma warning issued Doctors should carefully watch asthma patients who take the drug Singulair for signs of a rare but serious complication called Churg-Strauss syndrome, manufacturer Merck & Co. warned Thursday. Churg-Strauss syndrome is a tissue disorder that sometimes strikes adult asthma patients and, if untreated, can destroy organs. Merck said Thursday that it has received fewer than 20 reports of Singulair patients developing symptoms of Churg-Strauss, out of 600, 000 people worldwide who ….

151. Evening Standard, The (London, England) – January 27, 1998 EVENING STANDARD: BUSINESS DAY: DRUGS SET UP ZENECA FOR AN EARNINGS HIGH DRUGS group Zeneca said today a better-than-expected performance from its pharmaceuticals side, particularly new products, should enable it to report earnings above its “aspirational growth rate” of 15% this year. Following a downturn on the agrochemicals side, however, the group said its trading performance for 1997 is expected to be “in line with market expectations”. Sales growth on the pharmaceuticals side accelerated in the fourth ….. Aberdeen Press & Journal (Scotland) – September 30, 2004 Aberdeen Press & Journal (UK): Farmlay top egg producer A North-east egg producer has won its second business accolade in a month. Strichen-based Farmlay Eggs, which earlier this month won Scotland’s best small busi- ness crown, has now been named the country’s top egg producer. The new accolate came during the Scottish Egg Quality Awards, which were decided at the Scottish Agricultural College’s Auchincruive cam-pus. Farmlay, run by husband and wife Robert and Ethel Chapman, faced competition from 20 ….. – February 23, 1998 Big Movers in the Stock Market Some of the stocks that are moving substantially or trading heavily today on the New York Stock Exchange, Nasdaq Stock Market, and American Stock Exchange. NYSE Merck, up 4 at 128 11/16 The Food and Drug Administration cleared the drugmaker to begin selling its Singulair asthma drug next month. Singulair is one of a new class of oral asthma drugs that targets the causes of the disease, rather than symptoms. The first such drug to win FDA approval was Zeneca ….. Bridgeton News (NJ) – March 28, 2008 FDA probes possible link between allergy drug, suicide WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a ….. – March 28, 2008 FDA investigates possible Singulair, suicide link The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a class of asthma ….. – March 28, 2008 FDA probes suicide link to Singulair The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a class of asthma and ….. (FL) – May 5, 2007 How Should Pregnant Women Deal With Asthma? , By DENNIS LEDFORD, M. D. Tribune correspondent Asthma is one of the most common chronic conditions affecting pregnancy. Approximately 4 percent to 8 percent of pregnant women suffer from asthma. Women whose asthma is well controlled throughout pregnancy have an excellent chance for a normal pregnancy and a healthy baby. However, severe or poorly treated asthma is associated with premature birth, increased need for Caesarean sections, elevated blood pressure for the mother and growth retardation for the ….. wire Europe – February 23, 2006 SecurStar Wins International Security Award 2006 PRNewswire — Awarded in Best Disk Encryption, Best Email Security Solution, and Best Desktop Firewall Categories SecurStar GmbH with headquarter in Germany announced that the company’s products have gained SC Magazine Awards 2006. SecurStar’s encryption solutions have convinced readers as well as jury in all categories in which the company competed (best disk encryption, best email security solution, and best desktop firewall). With more than 1, 300 nominated products ….. MondayMorning (USA) – September 27, 1999 FDA ROUNDUP:. Careside Inc. (Culver City CA) was cleared to sell its test to detect carbon dioxide levels in blood. The test measures the total CO2 concentration in anti-coagulated blood, plasma, and serum, which aids in the diagnosis and treatment of patients with respiratory, kidney and metabolic disorders. * * Nidek Inc. (Fremont CA) received clearance to market its EAS-1000 Anterior Eye Segment Analysis System. The EAS-1000 is designed to provide clear, distinct anterior segment imaging of all pertinent ….. – February 23, 1998 Big Movers in the Stock Market Some of the stocks that are moving substantially or trading heavily today on the New York Stock Exchange, Nasdaq Stock Market, and American Stock Exchange. NYSE Merck, up 5 15/16 at 130 5/8 The Food and Drug Administration cleared the drugmaker to begin selling its Singulair asthma drug next month. Singulair is one of a new class of oral asthma drugs that targets the causes of the disease, rather than symptoms. The first such drug to win FDA approval was Zeneca ….

161. – February 23, 1998 Big Movers in the Stock Market Some of the stocks that moved substantially or traded heavily Monday on the New York Stock Exchange, Nasdaq Stock Market, and American Stock Exchange. NYSE Merck, up 5 15/16 at 130 5/8 The Food and Drug Administration cleared the drugmaker to begin selling its Singulair asthma drug next month. Singulair is one of a new class of oral asthma drugs that targets the causes of the disease, rather than symptoms. The first such drug to win FDA approval was Zeneca ….. Bismarck Tribune, The (ND) – April 1, 2008 Link between suicide, Singulair investigated WASHINGTON (AP) – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of a ….. Winchester (VA) – March 28, 2008 FDA probes Singulair, suicide WASHINGTON – The Food and Drug Administration is investigating a possible link between Merck’s best-selling Singulair drug and suicide. FDA said on Thursday that it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it is part of a class of ….. (NJ) – March 28, 2008 FDA probes possible link of Singulair with suicide The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken Merck’s popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, it’s part of ….. (CA) – February 10, 1997 NEW ASTHMA DRUGS CAN HELP PREVENT SYMPTOMS Regular use of one of the first of a new class of asthma drugs can help prevent symptoms in people with mild to moderate asthma, according to a new study. Of 146 asthmatics who used inhalers as needed, those who also took zafirlukast (sold as Accolate) daily for 13 weeks had 90 percent more days without asthma symptoms and 98 percent more days without episodes of asthma that disturbed their sleep or limited their activity than those who took placebo instead of zafirlukast. Zafirlukast ….. – June 15, 2009 FDA asks for warning on some asthma drugs The U. S. Food and Drug Administration has asked manufacturers to include a precaution in the labeling of some asthma drugs called leukotriene modifiers. The federal agency said the labeling should advise patients that some neuropsychiatric events have been reported by people taking montelukast (Singulair), zafirlukast (Accolate) and zileuton (Zyflo and Zyflo CR). Leukotrienes are chemicals the body releases in response to an inflammatory stimulus, such as when a person breathes in an ….. (MI) – March 28, 2008 In Brief FDA probing possible link between Singulair, suicide WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, ….. – June 23, 1997 ALLERGY POLICE // DOCTOR INVESTIGATES MEDICINES THAT COULD BRING SIGH OF RELIEF Dr. Anjuli Nayak likes to treat today’s patients with tomorrow’s medicine. Nayak is a local allergist. In her practice, she and her staff determine what patients are allergic to, then – if appropriate – give them injections of an allergen to gradually build up their immunity. That’s not unusual. There are several allergists in Bloomington-Normal. What is unusual is what goes on next door to her practice at 1300 Franklin Ave. , Suite 180, …. – March 28, 2008 FDA investigating link between allergy drug, suicide WASHINGTON — The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, ….. (WV) – March 28, 2008 FDA checking reported Singulair-suicide link WASHINGTON – The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the United States, according to Merck. First approved in 1998, it’s ….

171. (CA) – March 28, 2008 Allergy drug could be linked to suicide WASHINGTON � The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. The FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the U. S, according to Merck. First approved in 1998, ….. Financial Times (London, England) – June 10, 1998 STOCK MARKETS LONDON: Glaxo sought Other Financial, Fund Managers & Stockbrokers. Pharmaceuticals, Pharmaceuticals. Glaxo sought The new drug, Abacivir, could be on the market by the end of this year and Goldman, which is positive on the stock, projects sales of around Pounds 450m per year. However, not everyone is a fan of the international pharmaceuticals giant. Dresdner Kleinwort Benson was reported to have warned that interim results will be poor with both sales and operating profits down. It ….. – March 28, 2008 FDA looks at possible link between Singulair allergy drug and suicide By Matthew Perrone The Associated Press WASHINGTON The Food and Drug Administration said Thursday it is investigating a possible link between Merck’s best-selling Singulair and suicide. FDA said it is reviewing a handful of reports involving mood changes, suicidal behavior and suicide in patients who have taken the popular allergy and asthma drug. With sales of $4. 3 billion last year, Singulair is used by millions of patients in the United States, according to ….. Chemical Business NewsBase: US Food and Drug Administration News (United Kingdom) – March 27, 2008 Chemical Business NewsBase – US Food and Drug Administration News: Early communication about an ongoing safety review of montelukast (Singulair). On 27 Mar 2008, the US Food and Drugs Administration announced that it is investigating a possible association between the use of Singulair and behaviour/mood changes, suicidality (suicidal thinking and behaviour) and suicide. Singulair is a medicine in the drug class known as leukotriene receptor antagonists. Singulair is used to treat asthma and the symptoms of allergic rhinitis (sneezing, stuffy nose, runny nose, itching of the nose) and to prevent exercise-induced asthma. Over the past ….. AFX-CNF (UK) – January 31, 2008 AFX CNF: AstraZeneca PLC – Final Results – Part 2 of 3 RNS Number:9500M AstraZeneca PLC 31 January 2008 Consolidated Income Statement 2007 2006 For the year ended 31 December $m $m Sales 29, 559 26, 475 Cost of sales (6, 419) (5, 559) Distribution costs (248) (226) Research and development (5, 162) (3, 902) Selling, general and administrative costs (10, 364) (9, 096) Other operating income and expense 728 524 Operating profit 8, 094 8, 216 Finance income 959 888 Finance expense (1, 070) (561) Profit before tax 7, 983 8, 543 Taxation (2, 356) (2, 480) Profit for ….. AFX-CNF (UK) – November 1, 2007 AFX CNF: AstraZeneca PLC – 3rd Quarter Results – 2 of 2 RNS Number:8033G AstraZeneca PLC 01 November 2007 Consolidated Income Statement 2007 2006 For the nine months ended 30 September $m $m Sales 21, 389 19, 321 Cost of sales (4, 598) (3, 981) Distribution costs (181) (165) Research and development (3, 730) (2, 778) Selling, general and administrative costs (7, 309) (6, 585) Other operating income and expense 594 401 Operating profit 6, 165 6, 213 Finance income 703 621 Finance expense (722) (394) Profit before tax 6, 146 6, 440 Taxation (1, 794) (1, 822) Profit ….. – October 24, 2004 It’s a long, bumpy road for finding a new drug, For one 34-year veteran, there was 1 �blockbuster’ By TED GRIFFITH The News Journal For 34 years, Cyrus Ohnmacht has been showing up for work in Fairfax knowing that the odds are overwhelmingly against him. The pharmaceutical chemist for AstraZeneca spends part of his days in a laboratory, crowded with test tubes and bottles of chemical reagents, trying to find experimental compounds that might one day become new medicines. It’s often a fruitless quest. Ohnmacht and hundreds of other scientists at AstraZeneca test ….. (Bridgeport, CT) – April 20, 2004 Health Highlights: April 19, 2004 Here are some of the latest health and medical news developments, compiled by editors of HealthDay: Too Many Doctors Fail to Spread Weight-Loss Gospel Despite the obesity epidemic that’s playing havoc with many Americans’ health, too few doctors are advising their portly patients to lose weight, federal health officials said Monday. Only about 40 percent of doctors told their obese ….. – July 30, 1997 HEALTH NEWS NEW STUDY Geneticist Targets Gene In Righties And Lefties A single gene may separate most right-handers from lefties. Geneticist Amar J. S. Klar, who studied three generations of southpaws, says people with the gene are right-handed and those without it have a 50-50 chance of being either right-handed or left-handed. While others debate his theory, Klar, a researcher at the National Cancer Institute’s genetics laboratory in Frederick, Md. , is now trying to identify ….. The Commercial Appeal – December 12, 1994 Asthmatics: New drugs may give you relief Asthma is on the rise worldwide, aggravated by growing air pollution and allergies. There is no true cure for this most common chronic condition, affecting an estimated 3 to 5 percent of people, but a clutch of new drugs are now in development which doctors believe may improve treatment. At present, asthma is treated mainly with bronchodilators to relieve airway constriction, and, increasingly, with inhaled steroids which tackle the underlying inflammation of the bronchial tubes, which ….